Up to half of the applied solvent crosses the skin’s barrier and becomes systemic. For certain drug actives, this solvent provides for an intracutaneous depot. Use the link below to share a full-text version of this article with your friends and colleagues. Artificial Cells, Nanomedicine, and Biotechnology. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Diethylene glycol monoethyl ether (DGEE; see Fig. Journal of Drug Delivery Science and Technology. Conclusions: This safe, well-tolerated solvent is already used in many cosmetics and will become an ingredient in an increasing number of prescription products. Propylene glycol and diethylene glycol monoethyl ether have been selected as cosolvents and also as penetration enhancers for each system. Diethylene glycol monoethyl ether (Ethoxydiglycol) victoriayepez Member. Diethylene Glycol Monoethyl Ether has low setting point and low viscocity at low temperature so it is used in manufacturing Brake Fluid. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. Diethylene Glycol n-Butyl Ether YES <0.028 0.004 210/99 30.0 16.0 7.0 10.6 ∞ Non-food use Butyl CELLOSOLVE™ Solvent (BuCs) Ethylene Glycol n-Butyl Ether NO 0.66 0.079 149/65 27.4 16.0 7.6 12.3 ∞ 40 CFR 180.940* Applications Used as solvent and coupling agents in household and industrial cleaners. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Used in cosmetic and personal care products as well. 112-34-5 You may need a PDF reader to view some of the files on this page. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient. Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Diethylene glycol monoethyl ether: DEGEE: 112-07-2: Ethanol, 2-butoxy-, acetate: Ethylene glycol monobutyl ether acetate: EGBEA: 112-34-5: Ethanol, 2-(2-butoxyethoxy)- Diethylene glycol monobutyl ether: DEGBE: a The CAS RN is the property of the American Chemical Society and any use or redistribution, except as required in supporting regulatory requirements and/or for reports to the … Passive delivery of protein drugs through transdermal route. A literature search was conducted from the year prior to the OECD SIAM Footnote 22 (i.e., October 2004 to April 2016), and no health effects studies that would result in critical effect levels lower than those identified by OECD (2007) were identified. Store in a tightly closed container. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Epub 2017 Nov 6. Glycol ethers Last updated September 26, 2020. Diethyl Glycol Monoethyl Ether - CAS No. Learn more. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. August 2017. Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. 2019 Nov 13;11(11):607. doi: 10.3390/pharmaceutics11110607. Eastman DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. It is miscible in water (at 25°C) and organic solvents. If you do not receive an email within 10 minutes, your email address may not be registered, This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. It is a colorless liquid. To critically review technical and patent literature that provides insight into this novel solvent. No additives studied were found in the samples analysed. Eastman™ DE solvent is used as a coalescent in latex paints and floor polishes, and as penetrating solvent in wood stains. Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. 1/6. Aims To provide dermatologists a review of this solvent’s safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. An evaluation of dapsone gel 5% in the treatment of acne vulgaris. Background: Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. 111-90-0; Diethyl Glycol Monomethyl Ether - CAS No. BACKGROUND: The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. 2-Phenoxyethanol is a fixative for perfumes, cosmetics and soaps, a textile dye carrier and a solvent for cleaners, inks, germicides and pharmaceuticals. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. A second opinion (SCCP/1200/08) on Diethylene glycol monoethyl ether (DEGEE) for its use as solvent in hair dye formulations was adopted on 16 December 2008 with the conclusion that: "The SCCP is of the opinion that the use of diethylene glycol monoethyl ether (DEGEE) as a What options do I have to mask the odor, or are there replacements for ethoxydiglycol? First, diethylene glycol is metabolized by ADH to (2-hydroxyethoxy)acetaldehyde, which is then rapidly metabolized by aldehyde dehydrogenase to (2-hydroxyethoxy)acetate. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. Transcutol® has been applied in several commercial preparations and is used in many studies as the main ingredient of formulations. In this case, the substrate is ethanol, a type of alcohol. Applications. 2020 Feb;13(2):22-29. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. Commonly used in paints. Ethoxydiglycol, also known as diethylene glycol monoethyl ether or DEGEE, is produced by the ethoxylation of ethanol. The microemulsion prepared … It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. It is a popular solvent for commercial applications. Journal of Colloid and Interface Science. 2018 Nov;19(8):3512-3533. doi: 10.1208/s12249-018-1196-8. Ethyl Ethyl BMK Powder Ethyl 2-phenylacetoacetate CAS 5413-05-8 Top Quality. Diethyl Glycol Monoethyl Ether - CAS No. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. The Role of Microstructure in Topical Drug Product Development. . Print Share. Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Butylene Glycol ist ein Lösungsmittel, das feuchtigkeitsbindend wirkt. Its ability to modify the skin delivery of actives it is formulated with (or formulation components that are applied just shortly before or after) make it important for dermatologists to have an understanding of this emerging solvent. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. Synonyms. Structure, properties, spectra, suppliers and links for: 2-(2-Ethoxyethoxy)ethanol, 111-90-0, diethylene glycol monoethyl ether. 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